Osteoarthritis: some hints

sources: Orthopaedic Research Society and PR Newswire

According to Wikipedia, Osteoarthritis (OA) is a type of joint disease that results from breakdown of joint cartilage and underlying bone. The most common symptoms are joint pain and stiffness. Initially, symptoms may occur only following exercise, but over time may become constant. Other symptoms may include joint swelling, decreased range of motion, and when the back is affected weakness or numbness of the arms and legs. The most commonly involved joints are those near the ends of the fingers, at the base of the thumb, neck, lower back, knee, and hips. Joints on one side of the body are often more affected than those on the other. Usually the symptoms come on over years. It can affect work and normal daily activities. Unlike other types of arthritis, only the joints are typically affected.

OA affects the entire joint, progressively destroying the articular cartilage, including damage to the bone. Patients suffering from OA have decreased mobility as the disease progresses, eventually requiring a joint replacement since cartilage does not heal or regenerate. According to a 2010 Cleveland Clinic study, OA is the most prevalent form of arthritis in the United States, affecting more than 70% of adults between 55 and 78 years of age (that is, millions of people).

“My father was in major pain from his osteoarthritis,” explains Riccardo Gottardi, a scientist at the University of Pittsburgh supported by a Ri.MED Foundation fellowship.  “He was in so much pain that he had to undergo a double hip replacement followed by a knee replacement soon afterwards. I could see the debilitating and disabling effects the disease had on him, as he was restricted in his mobility and never fully recovered even after surgery. This was very different from the person that I knew, who had always been active and never shied away from long hours of work in his life – he just could not do it anymore.“

For scientists like Gottardi, a key obstacle in understanding the mechanisms of osteoarthritis and finding drugs that could heal cartilage, is that cartilage does not exist separately from the rest of the body. Cartilage interacts with other tissues of the joint, especially with bone. Bone and cartilage strongly influence each other and this needs to be taken into account when developing new drugs and therapies.

Gottardi and a team of researchers at the Center for Cellular and Molecular Engineering, led by Dr. Rocky Tuan, have developed a new generation system to produce engineered cartilage, bone and vasculature, organized in the same manner as they are found in the human joint.  This system is able to produce a high number of identical composite tissues starting from human cells. The team will use this system to study the interactions of cartilage with vascularized bone to identify potential treatments for osteoarthritis. The team’s research has two main objectives: to help understand how cartilage interacts with the other joint tissues, especially bone; and to help develop new effective treatments that could stop or even reverse the disease.  Their patent pending system is the first of its kind, and offers a number of advantages including the use of human cells that replicate native tissues. This system more closely matches the effects on humans than standard animal testing could achieve.

The team of scientists is further developing their system to produce tissues composed of more and different cell types that could better replicate the human joint. They have also started a number of collaborations with other research groups and companies that are interested in using the system to investigate other joint diseases and to test their product. “After seeing what my father went through,” says Gottardi, “I decided that I did not want to just watch by working on diagnostics, but rather, I wanted to be able to do something about osteoarthritis and contribute to the improvement of current treatment options.“

Gottardi’s work was recently presented at the Annual Meeting of the Orthopaedic Research Society. Founded in 1954, the Orthopaedic Research Society strives to be the world’s leading forum for the dissemination of new musculoskeletal research findings.

Workshop TIC & Santé

Quels défis technologiques pour améliorer

la qualité de vie de nos ainés ? 

Mercredi 20 Février 2013   – 9h / 16h30

Faculté de Médecine, Salle des Actes.

2 Rue de l’École de Médecine, Montpellier

9h – Accueil (Alain Bize, Pierre Baylet, Gilles Halbout)

9h30 – Introduction: “Les maladies chroniques : un enjeu de la médecine personnalisée” (Pr. Jacques Bringer)

9h45 – Session 1: “Robotique d’assistance et prothèses intelligentes” (Philippe Fraisse, Charles Fattal, Andrea Collo, Animateur: Philippe Poignet)

11h – Session 2: “Maladies chroniques et habitat intelligent” (Jacques Demongeot, Bessam Abdulrazak, Mounir Mokhtari, Stéphane Renouard, Animateur: Gérard Dray)

12h – Table ronde: “Comment associer recherche, formation et innovation dans le domaine des « TIC et Santé » ?” (Pierre Baylet, Geneviève Bodet, Daniel Laune, Claude Jeandel, Animateur: Christian Roux)

14h – Session 3: Démonstrations et Posters présentés par les étudiants de la formation Tic & Santé Montpellier (Animateur: Bruno Salgues)

14h45 – Session 4: “Technologies de la Santé, qualité de vie et médecine translationnelle” (Christian Jaurgensen, Yves Burnod, Eric Renard, Alain Faubeau, Animateur: Maurice Hayot)

16h – Conclusion et discussion (Francis Jutand)

site officiel de TIC & Santé Montpellier

BIODEVICES 2013 : check!

BIODEVICES is part of BIOSTEC, the International Joint Conference on Biomedical Engineering Systems and Technologies. The purpose of the International Conference on Biomedical Electronics and Devices is to bring together researchers and practitioners from electronics and mechanical engineering, interested in studying and using models, equipments and materials inspired from biological systems and/or addressing biological requirements. Monitoring devices, instrumentation sensors and systems, biorobotics, micro-nanotechnologies and biomaterials are some of the technologies addressed at this conference.

I’m here (in Barcelona) to present my paper! The conference atmosphere is nice and the presentations are really interesting. I especially like the possibility of having some good exchanges with others researchers working in the same fields of study 🙂

Mallet Finger: don’t try this at home

There are a few everyday life experiences that everybody is destined to go through every now and then. Like correctly plugging a USB device only at the third attempt (despite there are only two possibilities), or directly setting the alarm clock half an hour earlier because we know we’re used to putting it off at least four times, or having Mallet Finger.

Mallet Finger is probably one of the most painful and annoying injuries of all time. Technically, it is an injury of the extensor digitorum tendon of the fingers at the distal interphalangeal joint (DIP). In more simple terms, it is the typical injury that occurs when we play basketball and the ball suddenly hits our extended finger. Besides the immediate sensation of pain, within a few minutes our finger will start swelling and we won’t be able to straighten it for a while. We then leave the court with an awesome facial expression (it really hurts, you all know…), but do we know what happened inside our finger?

The distal interphalangeal joint (DIP) of the hand is nothing more than a hinge joint between the two last phalanges of the finger. This kind of joint only admits one degree of freedom, which is the rotation about the joint axis. As a result, our phalanges are allowed to make flexion and extension movements. Thus, the DIP is the last joint of the finger. A sudden high force acting at the tip of the finger (the ball we were trying to catch) strongly solicits the thin DIP extensor tendon. In case of rupture, or tearing, of this tendon from the bone, the finger usually gets painful, swollen, and bruised. Occasionally, blood can collect beneath the nail. In the worst case, the force of the blow may even pull away a piece of bone along with the tendon. The loss of extensor tendon continuity might lead to severe consequences and must be carefully treated. In a first moment, ice should be immediately applied and the hand should be elevated above the level of the heart. Medical attention should be sought within a week after injury. Most mallet finger injuries can be treated without surgery. Normally, X-rays are necessary in order to look for potential bone fractures or joint misalignment. The presence of blood beneath the nail and nail detachment may be a sign of nail bed laceration or open (compound) fracture. A splint can be applied to hold the fingertip straight (in extension) until it heals (8 weeks full-time, 3-4 further weeks less frequently). With this treatment plan, the finger usually regains an acceptable function and appearance. Despite that, it is not guaranteed that the patient will be able to regain full fingertip extension.

If nonsurgical treatment fails, after consultation with an orthopaedic surgeon the patient may consider to resort to surgical repair. In case of very severe deformity or inability to properly use the injured finger, surgery is done to repair the fracture using pins, pins and wire, or even small screws. Surgical treatment of the damaged tendon can include tightening the stretched tendon tissue, using tendon grafts, or even fusing the joint straight.

_

sources: mainly this website and this website, and then Google Images

the Ankle Joint: some hints

The ankle is the region where the foot and the leg meet. The ankle joint is actually composed by three smaller joints:

1. the ankle joint proper, commonly called ankle mortise joint (but also talocrural joint).  It is a synovial hinge joint that connects the distal ends of both the tibia and the fibula in the lower limb with the proximal end of the talus.
2. the subtalar joint, that occurs at the meeting point of the talus and the calcaneus.
3. the inferior tibiofibular joint, between the fibula and the tibia. More precisely, it is formed by the rough, convex surface of the medial side of the distal end of the fibula, and a (corresponding) rough concave surface on the lateral side of the tibia.

The boney architecture of the ankle consists of three bones: the tibia, the fibula (in the leg) and the talus (in the foot). The talus is also called the ankle bone since it’s the most important bone in the ankle articulation. In normal health conditions, the articulation between the tibia and the talus (ankle mortise joint) bears the greatest part of body weight: it is the region where ankle efforts are mostly concentrated.

The medial malleolus is a boney process extending distally off the medial tibia. There is also a lateral malleolus, generated by a distal-most aspect of the fibula. Together, the two malleoli, along with their supporting ligaments, stabilize the talus underneath the tibia.

The ankle joint is bound by the strong deltoid ligament (it is attached at the medial malleolus of the tibia and supports the medial side of the whole joint) and three lateral ligaments: the anterior and posterior talofibular ligaments (they support the lateral side of the joint, from the lateral malleolus to the dorsal and ventral ends of the talus) and the calcaneofibular ligament (it is attached at the lateral malleolus and to the lateral surface of the calcaneus).

The calcaneus is also attached to the Achille’s tendon (also known as the calcaneal tendon or the tendo calcaneus), that is a tendonous extension of gastrocnemius and soleus muscles of the leg. It attaches the heel to the posterior leg.

Concerning the joint motion, the ankle joint theoretically admits 1 degree of freedom: movements of plantar flexion and dorsiflexion.

In addition to these, the geometry of the different bones that form the articulation permits other more limited movements, such as foot eversion and inversion.

sources: Wikipedia and this website

the Knee Bursae: some hints

The bursae of the knee can be defined in a very simple way: they are fluid sacs, or synovial pockets. This second definition comes from the sinovial fluid that fills them.

Synovial fluid is made of hyaluronic acid and lubricin, proteinases and collagenases. Its main functions are reducing friction by lubricating the joint, absorbing shocks and properly “feeding” joint cartilage. In the case of the knee, the Knee Capsule encloses the Knee Cavity which is filled with synovial fluid. Knee Bursae surround and sometimes communicate with the Knee Cavity, as we can see in the picture.

Usually Knee Bursae are thin-walled and represent the weak point of the joint. At the same time, their presence is really important since they enlarge the joint space. They can be grouped according to:

• their characterization as communicating and non-communicating bursae. A communicating bursa is when a bursa is located adjacent to a joint, thus having the synovial membrane in communication with the joint itself.
• their location (frontal, lateral, medial).

In pathological conditions, such as excessive local friction, infection, arthritides or direct trauma, fluid and debris collect within the bursa or fluid extends into the bursa from the adjacent joint. As a consequence, the walls of the bursa thicken as the bursal inflammation becomes longstanding. The term bursitis refers to pathological enlargement of the bursa. Clinically, bursitis mimics several peripheral joint and muscle abnormalities.

   

<–prepatellar bursitis

          elbow bursitis–>

_

_

sources: Wikipedia and this website

accepted for publication

Title:

Towards a Dynamic Tibial Component for Postoperative Fine-tuning Adjustment of Knee Ligament Imbalance

Authors:

Andrea Collo, Shaban Almouahed, Chafiaa Hamitouche, Philippe Poignet, Eric Stindel

Accepted for Publication at:

BIODEVICES 2013 – 6th International Conference on Biomedical Electronics and Devices (conference official website)

Patellar Reflex

definition _

Patellar Reflex, also called knee-jerk, is a stretch reflex associated with quadriceps femoris muscle stretching.

how it works _

The stretch is created by a blow upon the patellar tendon (positioned just below the Patella). This blow, usually performed with a specific tendon hammer, activates the muscle spindle in the quadriceps femoris muscle.

Muscle spindle is a particular type of sensory receptor, normally embedded in muscle fibers, able to detect changes in the length of the muscle itself. Once “activated” by the external blow, this receptor sends a signal to the spinal cord. Instead of involving higher nervous centres (it would take too long), at the level of the spinal cord an alpha-motor neuron is immediately activated.

The alpha-motor neuron conducts an efferent impulse directly back to the quadriceps femoris muscle, leading to its contraction. At the same time, an inhibitory interneuron relaxes the hamstring muscle, which is the quadricep’s antagonistic muscle.

The result of such coordinated contraction-relaxation, causes the “kick movement” of the leg. In normal health conditions, the leg extends once and then comes back to rest. It only takes about 50 milliseconds between the tap and the start of the leg kick.

why it is useful _

Patellar Reflex is a proprioceptive reflex which helps keeping posture and balance. The fact that everything “happens” at the level of the spinal cord, without involving higher nervous centres, allows for instance to keep balance without effort (actually, one does not have to focus on keeping an upright position). Energies are saved for more complex activities. Moreover, Patellar Reflex helps avoiding strong muscle contractions which could tear the tendon.

clinical interest _

As said, there is no interneuron in the pathway leading to contraction of the quadriceps muscle. Patellar Reflex can be used, for example, to check the conditions of the connections between the spinal cord and the muscles.

The absence or decrease of the Patellar Reflex is known as Westphal’s sign. On the other hand, multiple oscillation of the leg following the blow may be a symptom of cerebellar diseases.

source: contents taken from Wikipedia’s page

the Patella: some hints

The patella (also known as knee cap) is a thick, circular-triangular bone which articulates with the femur and covers and protects the anterior articular surface of the knee joint.

It is the largest sesamoid bone in the human body. In the adult the articular surface is about 12 cm² and covered by cartilage, which can reach a maximal thickness of 6 mm in the centre at about 30 years of age.

The patella is attached to the Quadriceps tendon (of the quadriceps femoris muscle), which contracts to extend/straighten the knee. The vastus lateralis and vastus medialis are attached to lateral and medial borders of patella respectively. The vastus intermedialis muscle, not showed in this picture, is attached to the base of patella.

The patella is stabilized by the insertion of vastus medialis and the prominence of the anterior femoral condyles, which prevent lateral dislocation during flexion. The retinacular fibres of the patella also stabilize it during exercise.

The primary functional role of the patella is knee extension. The patella increases the leverage that the Quadriceps tendon can exert on the femur by increasing the angle at which it acts.

Patellar problems are among the most common causes of knee pain. This disease may be associated with other symptoms, such as instability or giveaway, dislocation, catching, grinding (crepitation), and/or swelling. These symptoms may present spontaneously or following injury (such as subluxations, blows to the front of the knee etc.). In general terms, patellar problems can be organized as:

1. Pain alone – “patellofemoral syndrome”,
2. Pain from malalignment – tilt and/or displacement,
3. Instability – subluxation and dislocation,
4. “Wear and tear” – arthritis,
5. Other problems – synovial plica, tendonitis, bursitis, Osgood Schlatter’s disease, etc.

Surgery is rarely necessary, and must be carefully considered. For example, for the “pain alone” case, surgery is rarely indicated since it may even make pain worse. In these terms, surgery is best used as a last resort, after all other techniques fail (normally: conservative care trials).

Arthroscopy is the very best way to evaluate the patella and surrounding portions of the knee joint. Surgery will vary depending upon the type of patellar problem.  Of course it has risks, such as infection, stiffness, continued instability, weakness, pain, blood clots, fracture, impaired bone healing, etc. Recovery ranges from 6 weeks to 6 months, or even longer, depending upon the type of surgery, healing rates and limitations, and patient rehabilitation and efforts.

sources: two websites, this one and this one

The power of Orthopaedic Surgery

What’s the use of worrying?
It never was worth while, so
Pack up your troubles in your old kit-bag,
And smile, smile, smile.

George Asaf – Smile, Smile, Smile